Some functionality available in CLC software requires access to specific addresses on the Internet.

Below, we provide a list of addresses the CLC software tools will try to access and the names or descriptions of tools that use those sites.
If the machines being used have direct access to the external network, then you should not need to do any further configuration to run the tools involved or download data, plugins, licenses and so on.  

For machines not directly connected to the external network, the list of sites below can be referred to when configuring firewall settings for networks that utilize a whitelist approach.

If you are using a CLC Server with a cluster or computing grid backend, the nodes in the cluster will also need access to the sites listed for particular functionality to work.
For example, if you wish to run Ingenuity Variant Analysis on a CLC Server with nodes, the nodes that could run this tool must be able to contact *.ingenuity.com.

The majority of these addresses are provided and controlled by third parties, and specific addresses may change without prior warning or notice.

Some third party plugins may require access to additional addresses, which are not included in the list. Further details for such plugins should be requested from the plugin provider.
Enable FTP*, HTTP and HTTPS for all desired functions from the lists below.

*FTP protocol requires the firewall to support REST, PASV, and RETR commands.
 

FunctionAddresses
Workbench updates, plugins, download license*.clcbio.com
*.qiagenbioinformatics.com
QIAGEN Reference data*.clcbio.com

reference.clcbio.com.s3-website.eu-central-1.amazonaws.com
genomics-cloud-reference-data-eu-central-1.s3-website.eu-central-1.amazonaws.com
Download Genome

*.clcbio.com

ftp.arabidopsis.org
ftp.ensemblgenomes.org
ftp.ensembl.org
ftp.ncbi.nih.gov
ftp.plantbiology.msu.edu
ftp.sanger.ac.uk
ftp.wormbase.org
hgdownload.cse.ucsc.edu

Download BLAST databasesftp.ncbi.nlm.nih.gov
Download Sequence Read Archive (SRA)sra-download.ncbi.nlm.nih.gov 
Download miRbasemirbase.org
BLAST at NCBIblast.ncbi.nlm.nih.gov
Search for sequences at NCBI; Search for PDB 3D protein structures at NCBIwww.ncbi.nlm.nih.gov
Download Pfam databaseftp.ebi.ac.uk
Uniprot database searchwww.uniprot.org

 

PluginsAddresses
Microbial Genomics Module (OTU amplicon-based databases)greengenes.microbio.me
www.arb-silva.de
unite.ut.ee
Microbial Genomics Module (MLST databases)*.pubmlst.org
Microbial Genomics Module (Pathogen Reference databases)*.ncbi.nlm.nih.gov
Microbial Genomics Module (Resistance databases)*.bitbucket.org
Microbial Genomics Module (Gene Ontology databases)*.purl.obolibrary.org
*.geneontology.org
Ingenuity Integration; Ingenuity Pathway Analysis*.ingenuity.com
SignalP 
TMHMM
*.cbs.dtu.dk
MLSTmlst.warwick.ac.uk
*.pubmlst.org
*.mlst.net
Blast2GO Pro*.ncbi.nlm.nih.gov
*.geneontology.org
*.ebi.ac.uk
pir.georgetown.edu
*.uniprot.org
*.expasy.org
*.pdb.org
*.rcsb.org